Commercial Space Transportation (CST) is stimulating increased activities in spaceflight and suborbital launches. With the implementation of mega constellations for space based broadband coverage, further growth is expected. Space vehicles will more frequently pass through civil airspace and will evolve from rare special events to regular airspace users. This development is creating an evident need for a safe and efficient integration of space vehicle operations into the air traffic system. DLR is addressing this topic applying a case study approach to analyze the effects of space vehicle operations on air traffic and to evaluate mitigation strategies and optimized Air Traffic Management (ATM) integration, as it will play a key role in the effort to ensure a sustainable CST system. The current state of the art of integrating spaceflight into ATM has to evolve to a concept that facilitates the requirements of trajectory based operations under the regimes of modern ATM systems in Europe and the US. A conceptual approach has been developed to utilize service oriented information distribution as backbone for improved planning and operational integration of space flight activities within an airspace and near-space environment, enhancing situational awareness for all relevant stakeholders while implementing procedures for a safe and efficient management of both – air traffic and space flight operation.